Ovarian Suppression - GnRH Antagonist

In some circumstances, an alternative to GnRH Agonist downregulation may be required or preferred. A GnRH antagonist prevents premature release (ovulation) of eggs by producing a rapid, reversible suppression of pituitary LH secretion. This medication is administered by subcutaneous (under the skin) injection. This is initiated during the controlled ovarian stimulation phase of the cycle. The specific protocol used will be determined according to your medical history and stimulation response.

Suppression Check - Pelvic Ultrasound

The patient is not suppressed during an antagonist cycle. However, a pelvic ultrasound is required within a day or two of starting menses and prior to stimulation medication to ensure that no new findings (such as an ovarian cyst) have developed that may interfere with treatment.

Medications/Side Effects

GnRH antagonists are commonly known as Orgalutran® or Cetrotide®. These medications may cause skin reactions such as redness, with or without swelling at the injection site, headache, nausea, dizziness, lack of energy or strength (asthenia) and malaise.